North Carolina State Route 280 is a north-south highway in Southern Buncombe County. It runs from the Buncombe/Henderson County Line, near Fletcher, to U.S. Rt. 25/U.S. Rt. 25A, at Arden. NC St Rt 280 passes through the following towns in Buncombe County. Fletcher Arden. NC St Rt 280 is not multi-plexed in Buncombe County. NC St Rt 280 intersects the following highways in Buncombe County. Interstate 26, near Fletcher. U.S. Rt. 74, near Fletcher. TRUCK U.S. Rt. 64, near Fletcher. U.S. Rt. 25, at Arden. U.S. Rt. 25A, at Fletcher.
