Ohio State Route 39 runs east-west across Southern Columbiana County. It runs from the Ohio/Pennsylvania State Line, near East Liverpool, to the Columbiana/Carroll County Line, near Salineville. OH St Rt 39 passes through the following towns in Columbiana County. East Liverpool
Ohio State Route 164, near Salineville. OH St Rt 39 intersects the following highways in Columbiana County. U.S. Rt. 30, at East Liverpool. Ohio State Route 11, at East Liverpool.
Ohio State Route 45, at Wellsville. Ohio State Route 7, at East Liverpool. Ohio State Route 164, near Salineville. Ohio State Route 164, at Salineville. Ohio State Route 664, at Salineville.
WB OH St Rt 39 at the Ohio Welcome Sign. WB OH St Rt 39 east of Bushwick Street. WB OH St Rt 39 near Dry Run. WB OH St Rt 39 near Andrews Street. WB OH St Rt 39 near Park Way. WB OH St Rt 39 east of east U.S. Rt. 30/OH St Rt 11. WB OH St Rt 39 before east U.S. Rt. 30/OH St Rt 11. WB OH St Rt 39 east of east U.S. Rt. 30/OH St Rt 11. WB U.S. Rt. 30/OH St Rt 39; NB OH St Rt 11 at the Ohio Welcome Sign. WB U.S. Rt. 30/OH St Rt 39; NB OH St Rt 11 near Broadway. SB OH St Rt 7/EB OH St Rt 39 south of U.S. Rt. 30; OH St Rt 11/267. SB OH St Rt 7/EB OH St Rt 39 south of East Liverpool. SB OH St Rt 7/EB OH St Rt 39 near Campground Road. SB OH St Rt 7/EB OH St Rt 39 at OH St Rt 45. SB OH St Rt 7/EB OH St Rt 39 at south OH St Rt 7. A BGS on SB OH St Rt 7/EB OH St Rt 39.