U.S. Federal Route 22 is a east-west highway through Guernsey County. This is the main route between Cambridge and Salt Fork Lake. U.S. Rt. 22 passes through the following towns in Guernsey County. Cassell Cambridge Winterset Antrim Londonderry Smyrna U.S. Rt. 22 is multi-plexed in Guernsey County. U.S. Rt. 40, from the Muskingum/Guernsey County Line to Cambridge. U.S. Rt. 22 intersects the following highways in Guernsey County. Ohio State Route 209, at Cambridge. U.S. Rt. 40, at Cambridge. Interstate 77, near Cambridge. Ohio State Route 285, at Winterset. Ohio State Route 513, at Antrim. Ohio State Route 800, at Smyrna.