U.S. Federal Route 22 is a east-west highway through Guernsey County. This is the main route between Cambridge and Salt Fork Lake. U.S. Rt. 22 passes through the following towns in Guernsey County. Cassell Cambridge
Winterset Antrim Londonderry Smyrna U.S. Rt. 22 is multi-plexed in Guernsey County. U.S. Rt. 40, from the Muskingum/Guernsey County Line to Cambridge.
A mileage chart on EB I-70. A BGS on EB I-70. WB U.S. Rt. 22/40 west of Cambridge. WB U.S. Rt. 22/40 at 6th. WB U.S. Rt. 22/40 east of 7th. WB U.S. Rt. 22/40 at 9th. WB U.S. Rt. 22/40 west of 11th. WB U.S. Rt. 22/40 west of 11th. A junction marker on WB U.S. Rt. 40. A BGS on NB I-77.