U.S. Federal Route 22 is a east-west highway in Central Jefferson County. It runs from the Harrison/Jefferson County Line, near Hopedale, to the Ohio/West Virginia State Line, at Steubenville. U.S. Rt. 22 passes through the following towns in Jefferson County. Bloomingdale Belvedere Steubenville
U.S. Rt. 22 is multi-plexed in Jefferson County. Ohio State Route 7, at Steubenville.
A BGS on SB OH St Rt 7. A guide marker on SB OH St Rt 7. EB U.S. Rt. 22/SB OH St Rt 7 north of University. EB U.S. Rt. 22/SB OH St Rt 7 at University. A BGS on EB U.S. Rt. 22/SB OH St Rt 7. The Veterans Memorial Bridge over the Ohio River. EB U.S. Rt. 22 at the Ohio River. WB U.S. Rt. 22 at the Ohio Welcome Sign.
