U.S. Federal Route 250 runs east-west across Northeastern Belmont County. It runs from the Belmont/Jefferson County Line, near Harrisville, to the Ohio/West Virginia State Line, near Bridgeport. U.S. Rt. 250 passes through the following towns in Belmont County. Colerain Bridgeport U.S. Rt. 250 is multi-plexed in Belmont County. U.S. Rt. 40, at Bridgeport.