U.S. Federal Route 40 runs east-west across Central Madison County. It runs from the Franklin/Madison County Line, near Lake Darby, to the Madison/Clark County Line, near Summerford. U.S. Rt. 40 passes through the following towns in Madison County. West Jefferson
Lafayette Summerford U.S. Rt. 40 is multi-plexed in Madison County. Ohio State Route 142, at West Jefferson.