U.S. Federal Route 40 is the main east-west surface highway across Central Muskingum County. This runs along the Interstate 70 corridor. U.S. Rt. 40 passes through the following towns in Muskingum County. Gratiot Hopewell Mount Sterling Zanesville Norwich New Concord U.S. Rt. 40 is multi-plexed in Muskingum County. U.S. Rt. 22, from Zanesville to the Muskingum/Guernsey County.