Pennsylvania State Route 45 is an east-west highway across Northern Northumberland County. It runs from the Union/Northumberland County Line, at Lewisburg, to the Nothumberland/Montour County Line, near Potts Grove. PA St Rt 45 passes through the following town in Northumberland County. Montandon PA St Rt 45 is not multi-plexed in Northumberland County. PA St Rt 45 intersects the following highways in Northumbeland County. Pennsylvania State Route 405, near Lewisburg. Pennsylvania State Route 147, near Montandon.
EB PA St Rt 45 east of PA St Rt 405. EB PA St Rt 45 near Vindale Ave. EB PA St Rt 45 west of PA St Rt 147.
