U.S. Federal Route 15 runs north-south in Eastern Perry County. This runs in two sections. The southern sections is in the southeastern portion of Perry County and runs from the Cumberland/Perry County Line, near Marysville, and runs north to the Perry/Dauphin County Line, near Duncannon. At the interchange with U.S. Rt. 22/322 in Dauphin County, U.S. Rt. 15 reenters Perry County and runs north to the Perry/Juniata County Line, near Oriental. U.S. Rt. 15 passes through the following towns in Perry County. Marysville Perdix Cover Duncannon New Buffalo Mt. Patrick Liverpool
U.S. Rt. 15 is multi-plexed in Perry County. U.S. Rt. 11, throughout Perry County.
A set of guide markers on EB PA St Rt 34. A guide marker on NB PA St Rt 34. NB U.S. Rt. 11/15 north of PA St Rt 34. NB U.S. Rt. 11/15 at Liverpool. NB U.S. Rt. 11/15 at PA St Rt 104.
