South Dakota State Route 38 is a east-west highway in West-Central Minnehaha County. The eastern end point is at Interstate 29 in Sioux Falls. This use to go through Sioux Falls to the South Dakota/Iowa State Line. In the mid-1990's this was pulled back to I-29. SD St Rt 38 passes through the following towns in Minnehaha County. Humboldt Hartford Sioux Falls SD St Rt 38 is multi-plexed in Minnehaha County. South Dakota State Route 19, near Humbolt. SD St Rt 38 intersects the following highways in Minnehaha County. South Dakota State Route 19, near Humbolt. South Dakota State Route 19, at Humbolt. Interstate 90, near Buffalo Ridge.