Tennessee State Route 43 runs north-south in Eastern Obion County. It runs un-signed along U.S. Rt. 45E for most of it's time in the county. TN St Rt 43 passes through the following towns in Obion County. South Fulton Mc Connell
TN St Rt 43 is multi-plexed in Obion County. U.S. Rt. 45E, from near South Fulton to the Obion/Weakly County Line. TN St Rt 43 intersects the following highways in Obion County. U.S. Rt. 45E, near South Fulton.