U.S. Federal Route 641 runs north-south in Central Henry County. It runs from the Benton/Henry County Line, near the Big Sandy River crossing, to the Kentucky/Tennessee State Line, at Hazel, Kentucky. U.S. Rt. 641 passes through the following towns in Henry County. Paris
SB U.S. Rt. 641/TN St Rt 54 at the Tennessee Welcome sign. NB U.S. Rt. 641/TN St Rt 54 south of Hazel, Kentucky. NB U.S. Rt. 641/TN St Rt 54 south of the Kentucky State Line. NB U.S. Rt. 641/TN St Rt 54 north of Puryear. NB U.S. Rt. 641/TN St Rt 54 north of TN St Rt 140. NB U.S. Rt. 641/TN St Rt 54 at TN St Rt 140. NB U.S. Rt. 641/TN St Rt 54 south of TN St Rt 140. NB U.S. Rt. 641/TN St Rt 54 south of Puryear. NB U.S. Rt. 641/TN St Rt 54 near the Obion River. NB U.S. Rt. 641/TN St Rt 54 north of TN St Rt 218. NB U.S. Rt. 641/TN St Rt 54 at TN St Rt 218. NB U.S. Rt. 641/TN St Rt 54 south of TN St Rt 218. NB U.S. Rt. 641/TN St Rt 54 near Old Paris Murray Road. NB U.S. Rt. 641/TN St Rt 54 north of Paris. NB U.S. Rt. 641/TN St Rt 54 near Washington in Paris. A junction marker on on NB TN St Rt 54/SB TN St Rt 69. NB U.S. Rt. 641/TN St Rt 69 south of TN St Rt 54/356. NB U.S. Rt. 641/TN St Rt 69 north of U.S. Rt. 79/TN St Rt 76. A junction marker on SB U.S. Rt. 79/TN St Rt 76. A set of guide markers on SB U.S. Rt. 79/TN St Rt 76. SB U.S. Rt. 79/TN St Rt 69 south of Spruce in Paris. SB U.S. Rt. 69/TN St Rt 69 near Memorial Park in Paris. A guide marker on SB U.S. Rt. 641/TN St Rt 69. A guide marker on NB TN St Rt 69A.