U.S. Federal Route 11 is a east-west highway across Central Wythe County. In the western portionof the county, this highway is a surface highway. East of Wytheville, this highway joins the Interstate 81 expressway. U.S. Rt. 11 passes through the following town in Wythe County. Wytheville U.S. Rt. 11 is multi-plexed in Wythe County. Interstate 77, from Wytheville to near Fort Chiswell. Interstate 81, from Wytheville to the Wythe/Pulaski County Line. U.S. Rt. 52, from Wytheville to near Fort Chiswell.