U.S. Federal Route 58 runs east-west across Central Lee County. It runs from the Tennessee/Virginia State Line, near Cumberland Gap, Tennessee, to the Lee/Scott County Line, near Stickleyville. U.S. Rt. 58 passes through the following towns in Lee County. Wheeler Ewing Rose Hill Jonesville Stickleyville U.S. Rt. 58 is multi-plexed in Lee County. U.S. Rt. 421, from near Stickleyville to the Lee/Scott County Line. Virginia State Route 684, near Ewing. Virginia State Route 612, at Stickleyville. U.S. Rt. 58 intersects the following highways in Lee County. Virginia State Route 693, near Wheeler. Virginia State Route 691, at Wheeler. Virginia State Route 699, near Wheeler. Virginia State Route 951, near Wheeler. Virginia State Route 690, near Wheeler. Virginia State Route 710, near Wheeler. Virginia State Route 690, near Wheeler. Virginia State Route 684, near Wheeler. Virginia State Route 684, near Ewing. Virginia State Route 955, near Ewing. Virginia State Route 698, near Ewing. Virginia State Route 953, near Ewing. BUSN U.S. Rt. 58, near Ewing. Virginia State Route 684, near Ewing. Virginia State Route 724, at Ewing. Virginia State Route 673, near Rose Hill. BUSN U.S. Rt. 58, near Rose Hill. Virginia State Route 667, near Rose Hill. Virginia State Route 670, near Rose Hill. Virginia State Route 621, near Rose Hill. Virginia State Route 814, near Rose Hill. Virginia State Route 899, near Rose Hill. Virginia State Route 899, near Rose Hill. Virginia State Route 880, near Rose Hill. Virginia State Route 758, near Rose Hill. Virginia State Route 880, near Rose Hill. Virginia State Route 652, near Joneville. Virginia State Route 745, near Jonesville. Virginia State Route 892, at Jonesville. ALT U.S. Rt. 58, at Jonesville. Virginia State Route 694, at Jonesville. Virginia State Route 70, near Jonesville. Virginia State Route 641, near Jonesville. Virginia State Route 641, near Jonesville. Virginia State Route 640, near Jonesville. Virginia State Route 783, near Jonesville. Virginia State Route 781, near Jonesville. Virginia State Route 791, near Jonesville. Virginia State Route 791, near Jonesville. Virginia State Route 643, near Jonesville. Virginia State Route 842, near Jonesville. Virginia State Route 793, near Jonesville. Virginia State Route 638, near Jonesville. U.S. Rt. 421, near Stickleyville. Virginia State Route 915, near Stickleyville. Virginia State Route 703, near Stickleyville. Virginia State Route 702, at Stickleyville. Virginia State Route 612, at Stickleyville. Virginia State Route 612, at Stickleyville.
Branches of U.S. Rt. 58 in Lee County. EB U.S. Rt. 58 at the Tennessee/Virginia State Line. EB U.S. Rt. 58 at the Virginia Welcome Sign. EB U.S. Rt. east of the Cumberland Gap.
