Wisconsin State Route 121 runs east-west across Northern Jackson County. It runs from Wisconsin State Route 95, near Alma Center, to the Jackson/Trempealeau County Line, near York. WI St Rt 121 passes through the following towns in Jackson County. Northfield York WI St Rt 121 is multi-plexed in Jackson County. WI St Rt 121 intersects the following highways in Jackson County. Wisconsin State Route 95, near Alma Center. Interstate 94, near Northfield.
