Wisconsin State Route 54 runs east-west across Southern Buffalo County. It goes from the Minnesota/Wisconsin State Line, near Winona, MN, to the Buffalo/Trempealeau County Line, near Marshland. WI St Rt 54 passes through the following town in Buffalo County. Bluff Siding WI St Rt 54 is multi-plexed in Buffalo County. Wisconsin State Route 35, near Bluff Siding.