Wisconsin State Route 78 is a north-south highway in Eastern Lafayette County. This runs from the Lafayette/Iowa County Line to the Illinois/Wisconsin State Line. WI St Rt 78 passes through the following towns in Lafayette County. Blanchardville Argyle Witoa Gratiot
EB WI St Rt 11/NB WI St Rt 78 east of west WI St Rt 11. A junction marker on EB WI St Rt 11. WB WI St Rt 11/SB WI St Rt 78 at west WI St Rt 11. NB WI St Rt 78 at west WI St Rt 11. NB WI St Rt 78 at Main Street in Gratiot. NB WI St Rt 78 south of Gratiot. SB WI St Rt 78 south of Gratiot. NB WI St Rt 78 near White School Road. NB WI St Rt 78 north of LCH W. NB WI St Rt 78 at LCH W. NB WI St Rt 78 north of the Illinois/Wisconsin State Line. SB WI St Rt 78 at the Illinois/Wisconsin State Line.