U.S. Federal Route 10 runs east-west across Northern Calumet County. It runs from the Calumet/Manitowoc County Line, near Brillion, to the Calumet/Winnebago County Line, near Menasha. U.S. Rt. 10 passes through the followings towns in Calumet County. Brillion
WB U.S. Rt. 10 at the Calumet/Manitowoc County Line. EB U.S. Rt. 10 east of Brillion. EB U.S. Rt. 10 east of Main St. WB U.S. Rt. 10 at Main St. A junction marker on Main St. WB U.S. Rt. 10 west of Billion. WB U.S. Rt. 10 east of Forest Junction. WB U.S. Rt. 10 at Forest Junction. WB U.S. Rt. 10 at WI St Rt 32/57.