U.S. Federal Route 10 runs east-west across Northern Trempealeau County. It runs from the Trempealeau/Monroe County Line, near Osseo, to the Buffalo/Trempealeau County, near Eleva. U.S. Rt. 10 passes through the following towns in Trempealeau County. Osseo Eleva U.S. Rt. 10 is multi-plexed in Trempealeau County. U.S. Rt. 53, near Osseo. U.S. Rt. 10 intersects the following highways in Trempealeau County. U.S. Rt. 53, near Osseo. U.S. Rt. 53, near Osseo. Wisconsin State Route 93, at Eleva.
