U.S. Federal Route 45 is a north-south highway in Central Fond du Lac County. It runs from the Washington/Fond du Lac County Line, near Kewaskum, to the Fond du Lac/Winnebago County Line, near Van Dyne. U.S. Rt. 45 passes through the following towns in Fond du Lac County. Waucousta Eden Fond du Lac
NB U.S. Rt. 45 at the Fond du Lac/Washington County Line. NB U.S. Rt. 45 at the Milwaukee River. NB U.S. Rt. 45 at FdLC Y. NB U.S. Rt. 45/EB WI St Rt 67 at east WI St Rt 67. A BGS on NB I-41/U.S. Rt. 41. A BGS on NB I-41/U.S. Rt. 41. A BGS on NB I-41/U.S. Rt. 41. NB I-41/U.S. Rt. 41-45 at Fond du Lac VVV. NB I-41/U.S. Rt. 41-45 north of Fond du Lac VVV. NB I-41/U.S. Rt. 41-45 north of Fond du Lac D. A BGS on NB I-41/U.S. Rt. 41-45. NB U.S. Rt. 45/EB WI St Rt 23 at Peters in Fond du Lac. NB U.S. Rt. 45/EB WI St Rt 23 west of Brooks. A junction marker in Fond du Lac. NB U.S. Rt. 45 south of Scott in Fond du Lac.