U.S. Rt. 41 runs straight through the center of this county. This is one place where the highway does not by-pass the major city. The by-pass is done by Interstate 164 to the east. U.S. Rt. 41 passes through the following town in Vanderburgh County. Evansville
NB U.S. Rt. 41 at I-64. NB U.S. Rt. 41 south of I-64. NB U.S. Rt. 41 south of Baseline Road. BGS on WB I-164. A BGS on SB I-69. A set of guide markers in Downtown Evansville. A set of guide markers on Veterans Memorial Parkway. A BGS on EB Veterans Memorial Parkway. A BGS on EB Veterans Memorial Parkway. The C/D Lane on EB Veterans Memorial Parkway at I-164/U.S. Rt. 41. SB U.S. Rt. 41, south of I-164 near the Indiana/Kentucky State Line. NB U.S. Rt. 41 at I-69. NB U.S. Rt. 41 at the Indiana Welcome Sign. NB U.S. Rt. 41 at the Indiana Welcome Sign.