U.S. Federal Route 431 runs due north-south from Huntsville to the Tennessee/Alabama State Line. From Huntsville south, this highway heads southeast to Marshall County. U.S. Rt. 431 passes through the following towns in Madison County. Fisk Hazel Green Medridanville Normal Huntsville Big Cove Owens Crossroads U.S. Rt 431 is multi-plexed in Madison County. U.S. Rt. 231, from the Tennessee/Alabama State Line to Huntsville.
Alabama State Route 1, from the Tennessee/Alabama State Line to the Marshall/Madison County Line. U.S. Rt. 72, at Huntsville. Alabama State Route 2, at Huntsville. U.S. Rt. 431 intersects the following highways in Madison County. U.S. Rt. 72, at Huntsville.
SB U.S. Rt. 231/431 near Fisk. SB U.S. Rt. 231/431 near Meridianville. SB U.S. Rt. 231/431, WB U.S. Rt. 72 in Huntsville on Memorial Parkway. SB U.S. Rt. 231/431, WB U.S. Rt. 72 near University Drive in Huntsville. BGS on EB I-565/ALT U.S. Rt. 72.
