Illinois State Route 121 is one of the main highways in Cumberland County. This connects the county seat, Toledo, to Effingham. IL St Rt 121 passes through the following towns in Cumberland County. Toledo
Greenup
IL St Rt 121 is multi-plexed in Cumberland County. U.S. Rt. 45, near Trilla.
IL St Rt 121 crosses the following highways in Cumberland County. U.S. Rt. 45, near Trilla.
EB IL St Rt 121 east of Toledo. The eastern end point in Greenup. The eastern end marker. The eastern end of IL St Rt 121. (December, 2024) The eastern end marker of IL St Rt 121. (December, 2024) NB IL St Rt 121 at Embarras Street. NB IL St Rt 121 north of 650N Road. A Cumberland County mile marker. NB IL St Rt 121 near Ohio in Toledo. NB IL St Rt 121 near Indiana in Toledo. NB IL St Rt 121 near Missouri in Toledo. NB IL St Rt 121 west of Toledo. NB IL St Rt 121 west of 1100E Rd. NB IL St Rt 121 near Muddy Creek. NB IL St Rt 121 east of 500E Rd. NB IL St Rt 121 south of south U.S. Rt. 45. NB IL St Rt 121 at south U.S. Rt. 45. NB U.S. Rt. 45/IL St Rt 121 north of south U.S. Rt. 45. SB U.S. Rt. 45/IL St Rt 121 at the Coles/Cumberland County Line.
