U.S. Federal Route 45 runs through the extreme northwestern corner of Cumberland County. U.S. Rt. 45 passes through the following town in Cumberland County. Neoga
U.S. Rt. 45 is multi-plexed in Cumberland County. Illinois State Route 121, from the Coles/Cumberland County Line to near Trilla.
U.S. Rt. 45 intersects the following highways in Cumberland County. Illinois State Route 121, near Trilla.
SB U.S. Rt. 45/IL St Rt 121 at the Coles/Cumberland County Line. NB U.S. Rt. 45/IL St Rt 121 north of south IL St Rt 121. A junction marker on NB IL St Rt 121. NB U.S. Rt. 45, north of I-57. BGS on SB I-57. A BGS on SB I-57. A BGS on SB I-57. SB U.S. Rt. 45 south of I-57. A Cumberland County mile marker. SB U.S. Rt. 45 north of Neoga. SB U.S. Rt. 45 at 6th in Neoga. SB U.S. Rt. 45 south of Neoga. NB U.S. Rt. 45 at the Cumberland/Shelby County Line.
