Illinois State Route 125 cuts east-west across the center on Cass County. This connects many towns along the way to each other and the county seat, Virginia. IL St Rt 125 passes through the following towns in Cass County. Philadelphia
IL St Rt 125 is not multi-plexed in Cass County. IL St Rt 125 intersects the following highways in Cass County. Illinois State Route 78, at Virginia.