Illinois State Route 78 is the main north-south route through Central and Eastern Cass County. This provides a western access to the Jim Edgar Panther Creek State Fish and Wildlife Area. IL St Rt 78 passes through the following towns in Cass County. Virginia
IL St Rt 78 is not multi-plexed in Cass County. IL St Rt 78 interstects the following highway in Cass County. Illinois State Route 125 at Virginia.