Illinois State Route 143 runs east-west across Madison County. This runs from Alton to near Highland. IL St Rt 143 passes through the following towns in Madison County. Alton
The western end of IL St Rt 143. The western end marker. A junction marker on WB IL St Rt 140. A guide marker on WB IL St Rt 140. WB IL St Rt 143 in Wood River. WB IL St Rt 143 at IL St Rt 255. A BGS on NB IL St Rt 255. A junction marker on EB IL St Rt 143/NB IL St Rt 157. EB IL St Rt 143 in Edwardsville. WB IL St Rt 143 near Ridge View Road. A Madison County mile marker. EB IL St Rt 143 east of Edwardsville. WB IL St Rt 143 west of Governors Parkway. WB IL St Rt 143 west of I-55. A BGS on SB I-55. A BGS on SB I-55. A BGS on SB I-55. A BGS on SB I-55. EB IL St Rt 143 near IL St Rt 4. A junction marker on NB IL St Rt 4. EB IL St Rt 143 near Marine. WB IL St Rt 143 west of I-70. A BGS on WB I-70. A BGS on EB I-70. A BGS on EB I-70. EB IL St Rt 143 near Highland Silver Lake. EB IL St Rt 143 near Highland. EB U.S. Rt. 40/IL St Rt 143; SB IL St Rt 160 at Highland. WB U.S. Rt. 40/IL St Rt 143 at south IL St Rt 160. EB U.S. Rt. 40/IL St Rt 143 near Highland. WB U.S. Rt. 40/IL St Rt 143 south of I-70. A BGS on WB I-70/U.S. Rt. 40. A BGS on WB I-70/U.S. Rt. 40. A BGS on EB I-70. A BGS on EB I-70. EB IL St Rt 143 near Pierron.
