Illinois State Route 143 runs east-west across Madison County. This runs from Alton to near Highland. IL St Rt 143 passes through the following towns in Madison County. Alton
The western end of IL St Rt 143. The western end marker. A junction marker on WB IL St Rt 140. A guide marker on WB IL St Rt 140. WB IL St Rt 143 in Wood River. WB IL St Rt 143 at IL St Rt 255. A BGS on NB IL St Rt 255. A junction marker on EB IL St Rt 143/NB IL St Rt 157. EB IL St Rt 143 in Edwardsville. A Madison County mile marker. EB IL St Rt 143 east of Edwardsville. A BGS on SB I-55. A BGS on SB I-55. EB IL St Rt 143 near IL St Rt 4. EB IL St Rt 143 near Marine. WB IL St Rt 143 west of I-70. A BGS on WB I-70. EB IL St Rt 143 near Highland Silver Lake. EB IL St Rt 143 near Highland. EB U.S. Rt. 40/IL St Rt 143; SB IL St Rt 160 at Highland. EB U.S. Rt. 40/IL St Rt 143 near Highland. A BGS on WB I-70/U.S. Rt. 40. A BGS on WB I-70/U.S. Rt. 40. EB IL St Rt 143 near Pierron.
