Illinois State Route 159 runs north-south across Central Madison County. This is one of the main surface highways in the county. At Edwardsville a new alignment is being built in the city. IL St Rt 159 passes through the following towns in Madison County. Midway Edwardsville
A BGS on SB I-55/WB I-70; U.S. Rt. 40. A BGS on SB I-55/WB I-70; U.S. Rt. 40. A junction marker on EB IL St Rt 162. A BGS on EB I-270. NB IL St Rt 159 in Glen Carbon.
