Illinois State Route 159 runs north-south across Central Madison County. This is one of the main surface highways in the county. At Edwardsville a new alignment is being built in the city. IL St Rt 159 passes through the following towns in Madison County. Midway Edwardsville
> SB IL St Rt 159 south of Morrison in Collinsville. SB IL St Rt 159 north of Morrison in Collinsville. > SB IL St Rt 159 south of Chestnut in Collinsville. > SB IL St Rt 159 near Park in Collinsville. SB IL St Rt 159 near Autumn in Collinsville. > SB IL St Rt 159 near California in Collinsville. NB IL St Rt 159 in Collinsville. NB IL St Rt 159 at I-55/70; U.S. Rt. 40. A BGS on SB I-55/WB I-70; U.S. Rt. 40. A BGS on SB I-55/WB I-70; U.S. Rt. 40. A BGS on NB I-55; EB I-70/U.S. Rt. 40. A BGS on SB I-55; WB I-70/U.S. Rt. 40. A junction marker on EB IL St Rt 162. A BGS on EB I-270. NB IL St Rt 159 in Glen Carbon.
