Illinois State Route 38 runs east-west across Northern Lee County. It goes from U.S. Rt. 52, in Dixon, to the Lee/Ogle County Line, near Ashton. This runs north of the Interstate 88/Illinois State Route 110 corridor IL St Rt 38 passes through the following towns in Lee County. Dixon
IL St Rt 38 is not multi-plexed in Lee County. IL St Rt 38 intersects the following highway in Lee County. U.S. Rt. 52, at Dixon.