U.S. Federal Route 52 runs north-south across Lee County. It runs in a angle from the northwest corner to the southeastern regions of the county. U.S. Rt. 52 passes through the following towns in Lee County. Dixon
Amboy
Sublette
U.S. Rt. 52 is not multi-plexed in Lee County. Illinois State Route 26, from the Lee/Ogle County Line to Dixon.
WB U.S. Rt. 52/NB IL St Rt 26 in Dixon. A junction marker on NB IL St Rt 2. NB IL St Rt 2/SB IL St Rt 26/EB U.S. Rt. 52 at the Rock River. EB U.S. Rt. 52/SB IL St Rt 25 in Downtown Dixon. EB U.S. Rt. 52 south of U.S. Rt. 30. EB U.S. Rt. 52 south of U.S. Rt. 30. WB U.S. Rt. 52 north of Amboy. A Lee County mile marker. EB U.S. Rt. 52 north of Sublette. WB U.S. Rt. 52 in Sublette. WB U.S. Rt. 52 near Sublette. WB U.S. Rt. 52 at the La Salle/Lee County Line.