U.S. Federal Route 52 runs north-south across Lee County. It runs in a angle from the northwest corner to the southeastern regions of the county. U.S. Rt. 52 passes through the following towns in Lee County. Dixon
EB U.S. Rt. 52 south of U.S. Rt. 30. A Lee County mile marker. EB U.S. Rt. 52 north of Sublette. WB U.S. Rt. 52 in Sublette. WB U.S. Rt. 52 near Sublette. WB U.S. Rt. 52 at the La Salle/Lee County Line.