Illinois State Route 49 is a north-south highway in Southeastern Coles County. It runs east of Ashmore. IL St Rt 49 does not pass through any towns in Coles County. IL St Rt 49 is multi-plexed in Coles County. Illinois State Route 16, near Ashmore.
IL St Rt 49 intersects the following highway in Coles County. Illinois State Route 16, near Ashmore.
A junction marker on EB IL St Rt 16. EB IL St Rt 16/NB IL St Rt 49 east of south IL St Rt 49. EB IL St Rt 16/NB IL St Rt 49 near the Coles/Edgar County Line. WB IL St Rt 16/SB IL St Rt 49 at the Coles/Edgar County Line.
