Illinois State Route 16 is the only east-west surface route in Coles County. This is the main link between Eastern Illinois University at Charleston and Interstate 57 near Matton. IL St Rt 16 passes through the following towns in Coles County. Mattoon
EB IL St Rt 16 at the Coles/Moultrie County Line. A junction marker on SB U.S. Rt. 45/EB IL St Rt 121. A junction marker on NB U.S. Rt. 45/WB IL St Rt 121. EB IL St Rt 16 east of south U.S. Rt. 45/IL St Rt 121. EB IL St Rt 16 near 3rd in Mattoon. EB IL St Rt 16 near Logan in Mattoon. WB IL St Rt 16 in Mattoon. A street sign in Mattoon. EB IL St Rt 16 west of I-57. EB IL St Rt 16 at I-57. BGS on SB I-57. A BGS on SB I-57. A BGS on SB I-57. WB IL St Rt 16 at I-57. A Coles County mile marker. EB IL St Rt 16 at Loxa Road. EB IL St Rt 16 west of Charleston. WB IL St Rt 16 west of Charleston. EB IL St Rt 16 east of Douglas in Charleston. EB IL St Rt 16 on the eastside of Charleston. EB IL St Rt 16 at IL St Rt 130. WB IL St Rt 16 at IL St Rt 130. EB IL St Rt 16 east of Charleston. EB IL St Rt 16 east of Ashmore. EB IL St Rt 16/NB IL St Rt 49 near the Coles/Edgar County Line.
