Illinois State Route 49 is a north-south highway Western Vermililon County. It runs in the central and northwestern portion of the county. Then again the northbound lanes runs in Vermilion County for aprox. three miles. IL St Rt 49 passes through the following towns in Vermilion County. Rankin
IL St Rt 49 is multi-plexed in Vermilion County. U.S. Rt. 136, near Armstrong.
U.S. Rt. 150, from near Fithian to the Vermilion/Champaign County Line.