U.S. Rt. 45 is one of few highways running through Massac County. This is the southern most county in Illinois that U.S. Rt. 45 runs through. U.S. Rt. 45 passes through the following towns in Massac County. Mermet
Metropolis
Brookport
U.S. Rt. 45 is not multi-plexed in Massac County U.S. Rt. 45 interstects the following highways in Massac County. Illinois State Route 169, near Mermet.
A Massac County mile marker. SB U.S. Rt. 45 north of Mermet. SB U.S. Rt. 45 north of Metropolis. SB U.S. Rt. 45 in Metropolis. SB U.S. Rt. 45 at 5th in Metropolis. NB U.S. Rt. 45 near Filmore in Metropolis. NB U.S. Rt. 45 near 12th in Metropolis. SB U.S. Rt. 45 west of I-24. NB U.S. Rt. 45 west of I-24. BGS on WB I-24. A BGS on EB I-24. A BGS on EB I-24. A BGS on WB I-24. A BGS on WB I-24. SB U.S. Rt. 45 east of I-24. SB U.S. Rt. 45 east of IL St Rt 145. SB U.S. Rt. 45 west of Deer Run Road. SB U.S. Rt. 45 north of Brookport. SB U.S. Rt. 45 near Unionville Road. SB U.S. Rt. 45 at Brookport. NB U.S. Rt. 45 at the Illinois Welcome Sign. SB U.S. Rt. 45 at the Ohio River. SB U.S. Rt. 45 at the Ohio River. SB U.S. Rt. 45 at the Ohio River.
