Roads of the Mid-South & West > Highways of the State of Indiana > Triple Number U.S. Federal Highways of Indiana > U.S. Federal Route 421, Indiana > U.S. Federal Route 421; Clinton County, Indiana

U.S. Federal Route 421
Clinton County

U.S. Federal Route 421 is a north-south highway in Central Clinton County. It runs from the Carroll/Clinton County Line, near Pince William, to the Boone/Clinton County Line, near Terhune.
U.S. Rt. 421 passes throug the following towns in Clinton County.
Rossville
Frankfort

Kirklin
U.S. Rt. 421 is multi-plexed in Clinton County.
Indiana State Route 39, from the Carroll/Clinton County Line to Frankfort.

Indiana State Route 28, from Frankfort to near Boyleston.

U.S. Rt. 421 ntersects the following highways in Clinton County.
Indiana State Route 26, at Rossville.
Indiana State Route 38, near Cambira.

Indiana State Route 75, at Frankfort.

Indiana State Route 28, at Frankfort.
Indiana State Route 39, at Frankfort.

Indiana State Route 29, near Boyleston.
Indiana State Route 28, near Boyleston.
Indiana State Route 38, at Kirklin.

A junction marker on EB IN St Rt 38.

A guide marker on EB IN St Rt 38.

SB U.S. Rt. 421/IN St Rt 39 south of IN St Rt 38.

SB U.S. Rt. 421/IN St Rt 39 near Kilmore Creek.

SB U.S. Rt. 421/IN St Rt 39 south of Kilmore Creek.

SB U.S. Rt. 421/IN St Rt 39 near 300N Road.

SB U.S. Rt. 421/IN St Rt 39 near St. Luke Church.

SB U.S. Rt. 421/IN St Rt 39 at the South Fork Wildcat Creek.

SB U.S. Rt. 421/IN St Rt 39 south of the SouthFork Wildcat Creek.

SB U.S. Rt. 421/IN St Rt 39 north of Frankfort.

SB U.S. Rt. 421/IN St Rt 39 near Magnolia Ave. in Frankfort.

SB U.S. Rt. 421/IN St Rt 39 near Railroad Street.

A guide marker on SB IN St Rt 75.

SB U.S. Rt. 421/IN St Rt 39 west of Jackson St in Frankfort.

SB U.S. Rt. 421/IN St Rt 39 south of Kyger St in Frankfort.
27 March 2025