U.S. Federal Route 421 is a north-south highway through Pulaski County. It runs along the Pulaski/Jasper County Line. This is a two-lane highway through out the county. U.S. Rt. 421 passes through the following towns in Pulaski County. Francesville
Medaryville Radioville
U.S. Rt. 421 is multi-plexed in Pulaski County. Indiana State Route 14, near Medaryville.
U.S. Rt. 421 intersects the following highways in Pulaski County. Indiana State Route 114, near Francesville.
SB U.S. Rt. 421 south of the Starke/Pulaski County Line. SB U.S. Rt. 421 soth of IN St Rt 143. A junction marker on EB IN St Rt 114. NB U.S. Rt. 421 north of IN St Rt 114. NB U.S. Rt. 421 near Francesville. NB U.S. Rt. 421/EB IN St Rt 14 near Medaryville.
