U.S. Federal Route 421 is a north-south highway in North-Central White County. It runs from the White/Pulaski County Line, near Monon, to Reynolds. At Reynolds, it runs east-west to Monticello. In Monticello, it runs north-south and enters Carroll County, near Patton. U.S. Rt. 421 passes through the following towns in White County. Monon
Reynolds
Monticello
U.S. Rt. 421 is multi-plexed in White County. U.S. Rt. 24, from Reynolds to Monticello.
A junction marker on EB IN St Rt 16. NB U.S. Rt. 421 south of IN St Rt 16. NB U.S. Rt. 421 near Reed Street in Monon. SB U.S. Rt. 421 near 4th in Monon. SB U.S. Rt. 421 near 3rd in Monon. A junction marker on EB U.S. Rt. 24. A guide marker on NB IN St Rt 43. EB U.S. Rt. 24/SB U.S. Rt. 421 east of IN St Rt 43. EB U.S. Rt. 24/SB U.S. Rt. 421 east of the CSX Railroad in Reynolds. EB U.S. Rt. 24/SB U.S. Rt. 421 east of Reynolds. EB U.S. Rt. 24/SB U.S. Rt. 421 west of Monticello. EB U.S. Rt. 24/SB U.S. Rt. 421 west of Monticello. EB U.S. Rt. 24/SB U.S. Rt. 421 west of 6th in Monticello. WB U.S. Rt. 24/NB U.S. Rt. 421 west of 6th in Monticello.