U.S. Federal Route 52 is a north-south highway that cuts in a angle across the county. This highway runs from the northwest corner and heads south to the southeast corner. In the southern portion of Boone County, U.S. Rt. 52 is aligned with Interstate 65 and Interstate 865. From Lebanon north, U.S. Rt. 52 is a four-lane highway providing a surface alternate to Interstate 65. U.S. Rt. 52 does not pass through any towns in Boone County. U.S. Rt. 52 is multi-plexed in Boone County. Interstate 865, from the Boone/Marion County Line to Interstate 65 near Royalton.
WB I-465/U.S. Rt. 52 at the Boone/Marion County Line. A BGS for EB U.S. Rt. 52 on EB I-865. BGS for WB U.S. Rt. 52 motorists on WB I-465. WB I-465/U.S. Rt. 52 at I-865. EB I-865/U.S. Rt. 52 at I-465. A BGS on EB I-865/U.S. Rt. 52. EB I-865/U.S. Rt. 52 near I-465. EB I-865/U.S. Rt. 52 east of I-65. SB I-65/EB U.S. Rt. 52 at I-865. SB I-65/EB U.S. Rt. 52 at I-865. SB I-65/EB U.S. Rt. 52 near I-865. SB I-65/EB U.S. Rt. 52 a half mile from I-865. A BGS on SB I-65/U.S. Rt. 52. A guide BGS on SB I-65/EB U.S. Rt. 52. SB I-65/EB U.S. Rt. 52 south of IN St Rt 267. A junction marker on S 400E Rd. NB I-65/WB U.S. Rt. 52 north of IN St Rt 267. SB I-65/EB U.S. Rt. 52 south of IN St Rt 39. SB I-65/EB U.S. Rt. 52 at IN St Rt 39. SB I-65/EB U.S. Rt. 52 south of IN St Rt 32. SB I-65/EB U.S. Rt. 52 at IN St Rt 32. BGS on NB I-65/WB U.S. Rt. 52. A BGS on NB I-65/WB U.S. Rt. 52. WB U.S. Rt. 52 near Hazelrigg.
