U.S. Federal Route 52 is a north-south highway that cuts in a angle across the county. This highway runs from the northwest corner and heads south to the southeast corner. In the southern portion of Boone County, U.S. Rt. 52 is aligned with Interstate 65 and Interstate 865. From Lebanon north, U.S. Rt. 52 is a four-lane highway providing a surface alternate to Interstate 65. U.S. Rt. 52 does not pass through any towns in Boone County. U.S. Rt. 52 is multi-plexed in Boone County. Interstate 865, from the Boone/Marion County Line to Interstate 65 near Royalton.