U.S. Federal Route 52 runs east-west in Northeastern Dearborn County. It runs from the Dearborn/Franklin County Line, near New Trenton, to the Indiana/Ohio State Line, near West Harrison. U.S. Rt. 52 does not pass through any towns in Dearborn County. U.S. Rt. 52 is multi-plexed in Dearborn County. Interstate 74, near West Harrison.
U.S. Rt. 52 intersects the following highways in Dearborn County. Indiana State Route 46, near West Harrison. Interstate 74, near West Harrison.