U.S. Federal Route 52 runs east-west in Northeastern Dearborn County. It runs from the Dearborn/Franklin County Line, near New Trenton, to the Indiana/Ohio State Line, near West Harrison. U.S. Rt. 52 does not pass through any towns in Dearborn County. U.S. Rt. 52 is multi-plexed in Dearborn County. Interstate 74, near West Harrison.