U.S. Federal Route 61 is a four-lane expressway throughout the county. At Muscatine, U.S. Rt. 61 by-passes the town to the north and west. U.S. Rt. 61 passes through the following town in Muscatine County. Muscatine
U.S. Rt. 61 is multi-plexed in Muscatine County. Iowa State Route 22, around Muscatine.
Branches of U.S. Rt. 61 in Muscatine County. NB U.S. Rt. 61/EB IA St Rt 92 at the Louisa/Muscatine County Line. SB U.S. Rt. 61/WB IA St Rt 92 south of Muscatine. SB U.S. Rt. 61/WB IA St Rt 92 at BUSN U.S. Rt. 61. NB U.S. Rt. 61/EB IA St Rt 92 on the southside of Muscatine. SB U.S. Rt. 61/WB IA St Rt 92 south of 25th. NB U.S. Rt. 61/EB IA St Rt 92 on the westside of Muscatine. SB U.S. Rt. 61/WB IA St Rt 92 south of IA St Rt 22. SB U.S. Rt. 61/WB IA St Rt 92 south of Cedar. SB U.S. Rt. 61; WB IA St Rt 22/92 at Cedar. NB U.S. Rt. 61; EB IA St Rt 22/92 on the northwest side of Muscatine. NB U.S. Rt. 61/EB IA St Rt 22 on the northside of Muscatine. SB U.S. Rt. 61 at BUSN U.S. Rt. 61; IA St Rt 22/38/92. NB U.S. Rt. 61 north of Muscatine. NB U.S. Rt. 61 near Fairport. NB U.S. Rt. 61 near Blue Grass.
