U.S. Federal Route 65 runs north-south in Central Warren County. It runs from the Metro-Des Moines Area, at the Polk/Warren County Line, to the Warren/Lucas County Line, south of Liberty Center. U.S. Rt. 65 passes through the following towns in Warren County. Des Moines
Liberty Center U.S. Rt. 65 is multi-plexed in Warren County. Iowa State Route 5, near Des Moines. U.S. Rt. 69, from Des Moines to near Indianola.