U.S. Federal Route 65 runs north-south in Central Warren County. It runs from the Metro-Des Moines Area, at the Polk/Warren County Line, to the Warren/Lucas County Line, south of Liberty Center. U.S. Rt. 65 passes through the following towns in Warren County. Des Moines
Indianola
Liberty Center U.S. Rt. 65 is multi-plexed in Warren County. Iowa State Route 5, near Des Moines. U.S. Rt. 69, from Des Moines to near Indianola.
U.S. Rt. 65 intersects the following highways in Warren County. U.S. Rt. 69, at Des Moines. Iowa State Route 5, at Des Moines.
SB U.S. Rt. 69 at the Polk/Warren County Line. SB U.S. Rt. 65/69 south of IA St Rt 5. SB U.S. Rt. 65/69 near Spring Hill. SB U.S. Rt. 65/69 north of Indianola. SB U.S. Rt. 65/69 in Indianola.