U.S. Federal Route 69 runs north-south in Warren County. It runs from the Polk/Warren County Line, at Metro-Des Moines to the Clarke/Warren County Line, near New Virginia. U.S. Rt. 69 passes through the following towns in Warren County. Des Moines
U.S. Rt. 69 is multi-plexed in Warren County. U.S. Rt. 65, from Des Moines to near Indianola.