Business U.S. Federal Route 641 runs through the downtown portion of Murray. It goes from U.S. Rt. 641, on the southside of Murray, along Glendale Road. Then it runs north-south on 4th Street. North of Downtown Murray, then it runs along Chestnut Street back to U.S. Rt. 641, near Murray State University. BUSN U.S. Rt. 641 passes through the following town in Calloway County. Murray BUSN U.S. Rt. 641 is multi-plexed in Calloway County. Kentucky State Route 121, at Murray. BUSN U.S. Rt. 641 intersects the following highways in Calloway County. U.S. Rt. 641, at Murray. Kentucky State Route 121, at Murray. Kentucky Secondary State Route 1550, at Murray.