U.S. Federal Route 25E runs in a south-east to north-west angle across Central Knox County. It runs from the Bell/Knox County Line, near Elys, to the Knox/Laurel County Line, at Corbin. U.S. Rt. 25E passes through the following towns in Knox County. Flat Lick Baughman Bimble Barbourville
NB U.S. Rt. 25E at the Bell/Knox County Line. NB U.S. Rt. 25E north of KY St Rt 223. NB U.S. Rt. 25E south of KY Sec St Rt 3439. NB U.S. Rt. 25E south of KY Sec St Rt 1304. A junction marker on SB KY Sec St Rt 1304. NB U.S. Rt. 25E north of KY Sec St Rt 1304. NB U.S. Rt. 25E north of KY Sec St Rt 3153. NB U.S. Rt. 25E near Castlewood Drive. NB U.S. Rt. 25E at west KY St Rt 11. NB U.S. Rt. 25E/KY St Rt 11 at north KY St Rt 11. NB U.S. Rt. 25E north of KY St Rt 11. NB U.S. Rt. 25E north of KY St Rt 229. NB U.S. Rt. 25E north of KY Sec St Rt 1527. NB U.S. Rt. 25E south of KY St Rt 223. A junction marker on NB KY St Rt 233. A set of guide markers on NB U.S. Rt. 25E. NB U.S. Rt. 25E at KY St Rt 830. NB U.S. Rt. 25E north KY Sec St Rt 3041.