U.S. Federal Route 60 runs east-west highway across Northern Daviess County. It runs from the Hancock/Daviess County Line, near Lewisport, to the Daviess/Henderson County Line, near Reed. Around Owensboro, U.S. Rt. 60 runs alond the Wendell H. Ford Expressway. U.S. Rt. 60 passes through the following towns in Daviess County. Maceo Owensboro Stanley U.S. Rt. 60 is multi-plexed in Daviess County. U.S. Rt. 231, (Wendell H. Ford Expressway) from Maceo to Owensboro.
U.S. Rt. 60 crosses the following highways in Daviess County. Kentucky State Route 334, near Maceo. (NO INTERCHANGE) Kentucky State Route 334, near Maceo. U.S. Rt. 231, (Wendell H. Ford Expressway) at Maceo.