Maryland State Route 80 is an east-west highway in Southern Frederick County. It runs Maryland State Route 85, near Buckeystown, to the Frederick/Montgomery County Line, near Kemptown. MD St Rt 80 passes through the following towns in Frederick County. Urbana Kempton MD St Rt 80 is multi-plexed in Frederick County. Maryland State Route 75, near Monrovia. MD St Rt 80 intersects the following highways in Frederick County. Maryland State Route 85, near Buckeystown. Interstate 270, near Urbana. Maryland State Route 355, at Urbana. Maryland State Route 75, near Monrovia. Maryland State Route 75, near Monrovia.