U.S. Federal Route 12 runs east-west across Branch County. It goes from the St. Joseph/Branch County Line, near Fawn River, to the Branch/Hillsdale County Line, near Allen. U.S. Rt. 12 passes through the following towns in Branch County. Bronson Batavia Coldwater
U.S. Rt. 12 is multi-plexed in Branch County. BUSN Loop I-69, at Coldwater.