U.S. Federal Route 12 runs east-west across Southern Cass County. This highway stays a few miles north of the Indiana/Michigan State Line. Most of the highway in two-lanes. U.S. Rt. 12 passes through the following towns in Cass County. Niles
Edwardsburg
Adamsville Union
U.S. Rt. 12 is not multi-plexed in Cass County. U.S. Rt. 12 intersects the following highways in Cass County. Michigan State Route 60, at Niles.
WB U.S. Rt. 12 at the Cass/St. Joseph County Line. WB U.S. Rt. 12 west of the Cass/St. Joseph County Line. EB U.S. Rt. 12 east of MI St Rt 40. WB U.S. Rt. 12 at MI St Rt 40. A guide marker on SB MI St Rt 40. WB U.S. Rt. 12 west of MI St Rt 40. WB U.S. Rt. 12 east of Union. WB U.S. Rt. 12 at Union. WB U.S. Rt. 12 in Union. WB U.S. Rt. 12 near Union. EB U.S. Rt. 12 east of MI St Rt 217. WB U.S. Rt. 12 at MI St Rt 217. A guide marker on NB MI St Rt 217. EB U.S. Rt. 12 at MI St Rt 217. WB U.S. Rt. 12 west of MI St Rt 217. A guide sign near Union. WB U.S. Rt. 12 near Kessington Road. WB U.S. Rt. 12 near Cassopolis Road. WB U.S. Rt. 12 near Adamsville. A junction marker on NB MI St Rt 62. EB U.S. Rt. 12 in Edwardsburg. WB U.S. Rt. 12 west of Edwardsburg. EB U.S. Rt. 12 west of Edwardsburg. EB U.S. Rt. 12 east of Niles. WB U.S. Rt. 12 east of MI St Rt. 60. WB U.S. Rt. 12 at MI St Rt 60. WB U.S. Rt. 12 at MI St Rt 60. A BGS on WB MI St Rt 60. A BGS on WB U.S. Rt. 12. A BGS on EB U.S. Rt. 12. EB U.S. Rt. 12 at MI St Rt 60. EB U.S. Rt. 12 at the Berrien/Cass County Line.
