U.S. Federal Route 12 runs east-west across Southern Cass County. This highway stays a few miles north of the Indiana/Michigan State Line. Most of the highway in two-lanes. U.S. Rt. 12 passes through the following towns in Cass County. Niles
U.S. Rt. 12 is not multi-plexed in Cass County. U.S. Rt. 12 intersects the following highways in Cass County. Michigan State Route 60, at Niles.