Mississippi State Route 53 is an east-west highway in Northwestern Harrison County. It runs from the Hancock/Harrison County Line, southeast of the Little Biloxi Wildlife Management Area to U.S. Rt. 49, at Lyman. MS St Rt 53 passes through the following town in Harrison County. Lyman MS St Rt 53 is not multi-plexed in Harrison County. MS St Rt 53 intersects the following highways in Harrison County. U.S. Rt. 49, at Lyman.
