U.S. Federal Route 49 is a north-south highway in Central Harrison County. It runs from the Stone/Harrison County Line, near Mc Henry to the southern end point of U.S. Rt. 49, in Gulfport. U.S. Rt. 49 passes through the following towns in Harrison County. Gulfport Lyman Saucier U.S. Rt. 49 is not multi-plexed in Harrison County. U.S. Rt. 49 intersects the following highways in Harrison County. U.S. Rt. 90, at Gulfport. Interstate 10, at Gulfport. Mississippi State Route 53, at Lyman.
